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1704 Publications visible to you, out of a total of 1704
Biomechanical Influences on Mesh-Related Complications in Incisional Hernia Repair

Abstract

Not specified

Authors: Friedrich Kallinowski, Yannique Ludwig, Dominik Gutjahr, Christian Gerhard, Hannah Schulte-Hörmann, Lena Krimmel, Carolin Lesch, Katharina Uhr, Philipp Lösel, Samuel Voß, Vincent Heuveline, Matthias Vollmer, Johannes Görich, Regine Nessel

Date Published: 29th Oct 2021

Publication Type: Journal

Kinetic and structural roles for the surface in guiding SAS-6 self-assembly to direct centriole architecture

Abstract (Expand)

iscovering mechanisms governing organelle assembly is a fundamental pursuit in biology. The centriole is an evolutionarily conserved organelle with a signature 9-fold symmetrical chiral arrangement of … microtubules imparted onto the cilium it templates. The first structure in nascent centrioles is a cartwheel, which comprises stacked 9-fold symmetrical SAS-6 ring polymers emerging orthogonal to a surface surrounding each resident centriole. The mechanisms through which SAS-6 polymerization ensures centriole organelle architecture remain elusive. We deploy photothermally-actuated off-resonance tapping high-speed atomic force microscopy to decipher surface SAS-6 self-assembly mechanisms. We show that the surface shifts the reaction equilibrium by ~104 compared to solution. Moreover, coarse-grained molecular dynamics and atomic force microscopy reveal that the surface converts the inherent helical propensity of SAS-6 polymers into 9-fold rings with residual asymmetry, which may guide ring stacking and impart chiral features to centrioles and cilia. Overall, our work reveals fundamental design principles governing centriole assembly.

Authors: Niccolò Banterle, Adrian P. Nievergelt, Svenja de Buhr, Georgios N. Hatzopoulos, Charlène Brillard, Santiago Andany, Tania Hübscher, Frieda A. Sorgenfrei, Ulrich S. Schwarz, Frauke Gräter, Georg E. Fantner, Pierre Gönczy

Date Published: 26th Oct 2021

Publication Type: Journal

Specifications of standards in systems and synthetic biology: status and developments in 2021.

Abstract (Expand)

This special issue of the Journal of Integrative Bioinformatics contains updated specifications of COMBINE standards in systems and synthetic biology. The 2021 special issue presents four updates of … standards: Synthetic Biology Open Language Visual Version 2.3, Synthetic Biology Open Language Visual Version 3.0, Simulation Experiment Description Markup Language Level 1 Version 4, and OMEX Metadata specification Version 1.2. This document can also be consulted to identify the latest specifications of all COMBINE standards.

Authors: F. Schreiber, P. Gleeson, M. Golebiewski, T. E. Gorochowski, M. Hucka, S. M. Keating, M. Konig, C. J. Myers, D. P. Nickerson, B. Sommer, D. Waltemath

Date Published: 22nd Oct 2021

Publication Type: Journal

Contact Map Fingerprints of Protein–Ligand Unbinding Trajectories Reveal Mechanisms Determining Residence Times Computed from Scaled Molecular Dynamics

Abstract

Not specified

Authors: Marc Bianciotto, Paraskevi Gkeka, Daria B. Kokh, Rebecca C. Wade, Hervé Minoux

Date Published: 12th Oct 2021

Publication Type: Journal

G Protein-Coupled Receptor–Ligand Dissociation Rates and Mechanisms from τRAMD Simulations

Abstract

Not specified

Authors: Daria B. Kokh, Rebecca C. Wade

Date Published: 12th Oct 2021

Publication Type: Journal

A construction principle for proper scoring rules

Abstract

Not specified

Author: Jonas Brehmer

Date Published: 12th Oct 2021

Publication Type: Journal

RAxML Grove: An empirical Phylogenetic Tree Database

Abstract

Not specified

Authors: Dimitri Höhler, Wayne Pfeiffer, Vassilios Ioannidis, Heinz Stockinger, Alexandros Stamatakis

Date Published: 6th Oct 2021

Publication Type: Journal

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