Molecular Biomechanics

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SEEK ID: https://publications.h-its.org/projects/9

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Project created: 7th Nov 2017

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Csaba Daday

Projects: Molecular Biomechanics

Institutions: Heidelberg Institute for Theoretical Studies

Svenja de Buhr

Projects: Molecular Biomechanics

Institutions: Heidelberg Institute for Theoretical Studies

Krisztina Feher

Projects: Molecular Biomechanics

Institutions: Heidelberg Institute for Theoretical Studies

Florian Franz

Projects: Molecular Biomechanics

Institutions: Heidelberg Institute for Theoretical Studies

Frauke Gräter

Projects: Molecular Biomechanics

Institutions: Heidelberg Institute for Theoretical Studies

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Heidelberg Institute for Theoretical Studies

Country: Germany

City: Heidelberg

Web page: https://www.h-its.org

HITS

Country: Afghanistan

City: Not specified

Web page: Not specified

Myristoyl's dual role in allosterically regulating and localizing Abl kinase

Molecular Biomechanics

Abstract (Expand)

c-Abl kinase, a key signalling hub in many biological processes ranging from cell development to proliferation, is tightly regulated by two inhibitory Src homology domains. An N-terminal myristoyl-modification …

Authors: Svenja de Buhr, Frauke Gräter

Date Published: 16th Oct 2023

Publication Type: Journal

DOI: 10.7554/eLife.85216

Citation: eLife 12:e85216.

Created: 2nd Jan 2023 at 23:16, Last updated: 17th Oct 2023 at 07:25

The role of flow in the self-assembly of dragline spider silk proteins

Molecular Biomechanics

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Abstract (Expand)

Hydrodynamic flow in the spider duct induces conformational changes in dragline spider silk proteins (spidroins) and drives their assembly, but the underlying physical mechanisms are still elusive. …

Authors: Ana M. Herrera-Rodríguez, Anil Kumar Dasanna, Csaba Daday, Eduardo R. Cruz-Chú, Camilo Aponte-Santamaría, Ulrich S. Schwarz, Frauke Gräter

Date Published: 5th Oct 2023

Publication Type: Journal

DOI: 10.1016/j.bpj.2023.09.020

Citation: Biophysical Journal

Created: 17th Oct 2023 at 07:29

Allosteric activation of vinculin by talin

Molecular Biomechanics

Abstract (Expand)

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule …

Authors: Florian Franz, Rafael Tapia-Rojo, Sabina Winograd-Katz, Rajaa Boujemaa-Paterski, Wenhong Li, Tamar Unger, Shira Albeck, Camilo Aponte-Santamaría, Sergi Garcia-Manyes, Ohad Medalia, Benjamin Geiger, Frauke Gräter

Date Published: 18th Jul 2023

Publication Type: Journal

DOI: 10.1038/s41467-023-39646-4

Citation: Nat Commun 14, 4311 (2023)

Created: 5th Aug 2022 at 08:25, Last updated: 24th Jul 2023 at 07:17

Collagen breaks at weak sacrificial bonds taming its mechanoradicals

Molecular Biomechanics, Computational Carbon Chemistry

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Abstract (Expand)

Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic …

Authors: Benedikt Rennekamp, Christoph Karfusehr, Markus Kurth, Aysecan Ünal, Kai Riedmiller, Ganna Gryn’ova, David M. Hudson, Frauke Gräter

Date Published: 12th Apr 2023

Publication Type: Journal

DOI: 10.1038/s41467-023-37726-z

Citation: Nat Commun 14, 2075 (2023).

Created: 21st Oct 2022 at 17:53, Last updated: 14th Apr 2023 at 06:38

Disulfide Bond Reduction and Exchange in von-Willebrand-Factor’s C4-Domain Undermines Platelet Binding

Molecular Biomechanics

Abstract

Not specified

Authors: Fabian Kutzki, Diego Butera, Angelina J. Lay, Denis Maag, Joyce Chiu, Heng-Giap Woon, Tomáš Kubař, Marcus Elstner, Camilo Aponte-Santamaría, Philip J. Hogg, Frauke Gräter