Molecular Biomechanics

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SEEK ID: https://publications.h-its.org/projects/9

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Project created: 7th Nov 2017

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Csaba Daday

Projects: Molecular Biomechanics

Institutions: Heidelberg Institute for Theoretical Studies

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Institutions: Heidelberg Institute for Theoretical Studies

Krisztina Feher

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Institutions: Heidelberg Institute for Theoretical Studies

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Institutions: Heidelberg Institute for Theoretical Studies

Frauke Gräter

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Heidelberg Institute for Theoretical Studies

Country: Germany

City: Heidelberg

Web page: https://www.h-its.org

HITS

Country: Afghanistan

City: Not specified

Web page: Not specified

DOPA residues endow collagen with radical scavenging capacity

Molecular Biomechanics

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Abstract (Expand)

Here we uncover collagen, the main structural protein of all connective tissues, as a redox-active material. We identify dihydroxyphenylalanine (DOPA) residues, post-translational oxidation products …

Authors: Markus Kurth, Uladzimir Barayeu, Hassan Gharibi, Andrei Kuzhelev, Kai Riedmiller, Jennifer Zilke, Kasimir Noack, Vasyl Denysenkov, Reinhard Kappl, Thomas F. Prisner, Roman A. Zubarev, Tobias P. Dick, Frauke Gräter

Date Published: 23rd Jan 2023

Publication Type: Journal

DOI: 10.1101/2023.01.23.524231

Citation:

Created: 24th Jan 2023 at 08:31

Myristoyl’s dual role in allosterically regulating and localizing Abl kinase

Molecular Biomechanics

Abstract (Expand)

c-Abl kinase, a key signalling hub in many biological processes ranging from cell development to proliferation, is tightly regulated by two inhibitory Src homology domains. An N-terminal myristoyl-modification …

Authors: Svenja de Buhr, Frauke Gräter

Date Published: 20th Dec 2022

Publication Type: Journal

DOI: 10.1101/2022.12.20.521177

Citation:

Created: 2nd Jan 2023 at 23:16

Bond dissociation energies of X–H bonds in proteins

Molecular Biomechanics

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Knowledge of reliable X−H bond dissociation energies (X = C, N, O, S) for amino acids in proteins is key for studying the radical chemistry of proteins. X−H bond dissociation energies of model dipeptides …

Authors: Authors Wojtek Treyde, Kai Riedmiller, Frauke Gräter

Date Published: 1st Dec 2022

Publication Type: Journal

DOI: 10.1039/D2RA04002F

Citation: RSC Advances,12(53):34557-34564

Created: 8th Aug 2022 at 14:31, Last updated: 2nd Dec 2022 at 10:56

Structure and dynamics of the von Willebrand Factor C6 domain

Molecular Biomechanics

Abstract (Expand)

Von Willebrand disease (VWD) is a bleeding disorder with different levels of severity. VWD-associated mutations are located in the von Willebrand factor (VWF) gene, coding for the large multidomain …

Authors: Po-Chia Chen, Fabian Kutzki, Angelika Mojzisch, Bernd Simon, Emma-Ruoqi Xu, Camilo Aponte-Santamaría, Kai Horny, Cy Jeffries, Reinhard Schneppenheim, Matthias Wilmanns, Maria A. Brehm, Frauke Gräter, Janosch Hennig

Date Published: 18th Nov 2022

Publication Type: Journal

DOI: 10.1016/j.jsb.2022.107923

Citation: Journal of Structural Biology,214(4):107923

Created: 22nd Nov 2022 at 07:28

Collagen breaks at weak sacrificial bonds taming its mechanoradicals

Molecular Biomechanics

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Abstract (Expand)

Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic …

Authors: Benedikt Rennekamp, Christoph Karfusehr, Markus Kurth, Aysecan Ünal, Kai Riedmiller, Ganna Gryn’ova, David M. Hudson, Frauke Gräter

Date Published: 18th Oct 2022

Publication Type: Journal

DOI: 10.1101/2022.10.17.512491

Citation:

Created: 21st Oct 2022 at 17:53, Last updated: 25th Oct 2022 at 14:12

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