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1702 Publications visible to you, out of a total of 1702
Large-scale geometry of the saddle connection graph

Abstract

Not specified

Authors: Valentina Disarlo, Huiping Pan, Anja Randecker, Robert Tang

Date Published: 1st Nov 2021

Publication Type: Journal

Curvature formulas related to a family of stable Higgs bundles

Abstract

Not specified

Authors: Zhi Hu, Pengfei Huang

Date Published: 1st Nov 2021

Publication Type: Journal

Testing the evolution theory of massive binary systems

Abstract

Not specified

Authors: L. Mahy, H. Sana, F. Martins, G. Rauw, M. Abdul-Masih, L. A. Almeida, N. Langer, K. Sen, T. Shenar, A. de Koter, S. E. de Mink, C. J. Evans, A. F. J. Moffat, S. Simón-Dı́az, F. R. N. Schneider, R. Barbá, J. S. Clark, M. Fabry, P. Crowther, G. Gräfener, D. J. Lennon, F. Tramper, J. S. Vink

Date Published: 1st Nov 2021

Publication Type: InProceedings

Empirical Numerical Properties of Maximum Likelihood Phylogenetic Inference

Abstract (Expand)

Phylogenetic trees represent hypothetical evolutionary relationships between organisms. Approaches for inferring phylogenetic trees include the Maximum Likelihood (ML) method. This method relies on … numerical optimization routines that use internal numerical thresholds. We analyze the influence of these thresholds on the likelihood scores and runtimes of tree inferences for the ML inference tools RAxML-NG, IQ-Tree, and FastTree. We analyze 22 empirical datasets and show that we can speed up the tree inference in RAxML-NG and IQ-Tree by changing the default values of two such numerical thresholds. Using 15 additional simulated datasets, we show that these changes do not affect the accuracy of the inferred phylogenetic trees. For RAxML-NG, increasing the likelihood thresholds lh_epsilon and spr_lh_epsilon to 10 and 103 respectively results in an average speedup of 1.9 ± 0.6. Increasing the likelihood threshold lh_epsilon in IQ-Tree results in an average speedup of 1.3 ± 0.4. In addition to the numerical analysis, we attempt to predict the difficulty of datasets, with the aim of preventing an unnecessarily large number of tree inferences for datasets that are easy to analyze. We present our prediction experiments and discuss why this task proved to be more challenging than anticipated.

Author: Julia Haag

Date Published: 31st Oct 2021

Publication Type: Master's Thesis

Disentangling the optical AGN and host-galaxy luminosity with a probabilistic flux variation gradient

Abstract

Not specified

Authors: N. Gianniotis, F. Pozo Nuñez, K. L. Polsterer

Date Published: 29th Oct 2021

Publication Type: Journal

Biomechanical Influences on Mesh-Related Complications in Incisional Hernia Repair

Abstract

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Authors: Friedrich Kallinowski, Yannique Ludwig, Dominik Gutjahr, Christian Gerhard, Hannah Schulte-Hörmann, Lena Krimmel, Carolin Lesch, Katharina Uhr, Philipp Lösel, Samuel Voß, Vincent Heuveline, Matthias Vollmer, Johannes Görich, Regine Nessel

Date Published: 29th Oct 2021

Publication Type: Journal

Kinetic and structural roles for the surface in guiding SAS-6 self-assembly to direct centriole architecture

Abstract (Expand)

iscovering mechanisms governing organelle assembly is a fundamental pursuit in biology. The centriole is an evolutionarily conserved organelle with a signature 9-fold symmetrical chiral arrangement of … microtubules imparted onto the cilium it templates. The first structure in nascent centrioles is a cartwheel, which comprises stacked 9-fold symmetrical SAS-6 ring polymers emerging orthogonal to a surface surrounding each resident centriole. The mechanisms through which SAS-6 polymerization ensures centriole organelle architecture remain elusive. We deploy photothermally-actuated off-resonance tapping high-speed atomic force microscopy to decipher surface SAS-6 self-assembly mechanisms. We show that the surface shifts the reaction equilibrium by ~104 compared to solution. Moreover, coarse-grained molecular dynamics and atomic force microscopy reveal that the surface converts the inherent helical propensity of SAS-6 polymers into 9-fold rings with residual asymmetry, which may guide ring stacking and impart chiral features to centrioles and cilia. Overall, our work reveals fundamental design principles governing centriole assembly.

Authors: Niccolò Banterle, Adrian P. Nievergelt, Svenja de Buhr, Georgios N. Hatzopoulos, Charlène Brillard, Santiago Andany, Tania Hübscher, Frieda A. Sorgenfrei, Ulrich S. Schwarz, Frauke Gräter, Georg E. Fantner, Pierre Gönczy

Date Published: 26th Oct 2021

Publication Type: Journal

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