DOPA Residues Endow Collagen with Radical Scavenging Capacity

Abstract:

Here we uncover collagen, the main structural protein of all connective tissues, as a redox-active material. We identify dihydroxyphenylalanine (DOPA) residues, post-translational oxidation products of tyrosine residues, to be common in collagen derived from different connective tissues. We observe that these DOPA residues endow collagen with substantial radical scavenging capacity. When reducing radicals, DOPA residues work as redox relay: they convert to the quinone and generate hydrogen peroxide. In this dual function, DOPA outcompetes its amino acid precursors and ascorbic acid. Our results establish DOPA residues as redox-active side chains of collagens, probably protecting connective tissues against radicals formed under mechanical stress and/or inflammation.

SEEK ID: https://publications.h-its.org/publications/1566

DOI: 10.1002/anie.202216610

Research Groups: Molecular Biomechanics

Publication type: Journal

Journal: Angewandte Chemie International Edition

Publisher: Wiley

Citation: Angew. Chem. Int. Ed. 2023, e202216610

Date Published: 3rd Apr 2023

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Registered Mode: manually

Authors: Markus Kurth, Uladzimir Barayeu, Hassan Gharibi, Andrei Kuzhelev, Kai Riedmiller, Jennifer Zilke, Kasimir Noack, Vasyl Denysenkov, Reinhard Kappl, Thomas F. Prisner, Roman A. Zubarev, Tobias P. Dick, Frauke Gräter

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Kurth, M., Barayeu, U., Gharibi, H., Kuzhelev, A., Riedmiller, K., Zilke, J., Noack, K., Denysenkov, V., Kappl, R., Prisner, T. F., Zubarev, R. A., Dick, T. P., & Gräter, F. (2023). DOPA Residues Endow Collagen with Radical Scavenging Capacity**. In Angewandte Chemie International Edition (Vol. 62, Issue 24). Wiley. https://doi.org/10.1002/anie.202216610
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Created: 24th Jan 2023 at 08:31

Last updated: 5th Mar 2024 at 21:25

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