Publications

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435 Publications visible to you, out of a total of 435

Abstract

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Authors: Andreas Bauswein, Niels-Uwe F. Bastian, David B. Blaschke, Katerina Chatziioannou, James A. Clark, Tobias Fischer, Micaela Oertel

Date Published: 1st Feb 2019

Publication Type: Journal

Abstract

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Authors: Andoni Torres-Rivas, Katerina Chatziioannou, Andreas Bauswein, James Alexander Clark

Date Published: 1st Feb 2019

Publication Type: Journal

Abstract (Expand)

Von Willebrand factor (VWF) is a key player in the regulation of hemostasis by promoting recruitment of platelets to sites of vascular injury. An array of 6 C domains forms the dimeric C-terminal VWF stem. Upon shear force activation, the stem adopts an open conformation allowing the adhesion of VWF to platelets and the vessel wall. To understand the underlying molecular mechanism and associated functional perturbations in disease-related variants, knowledge of high-resolution structures and dynamics of C domains is of paramount interest. Here, we present the solution structure of the VWF C4 domain, which binds to the platelet integrin and is therefore crucial for the VWF function. In the structure, we observed 5 intra- and inter-subdomain disulfide bridges, of which 1 is unique in the C4 domain. The structure further revealed an unusually hinged 2-subdomain arrangement. The hinge is confined to a very short segment around V2547 connecting the 2 subdomains. Together with 2 nearby inter-subdomain disulfide bridges, this hinge induces slow conformational changes and positional alternations of both subdomains with respect to each other. Furthermore, the structure demonstrates that a clinical gain-of-function VWF variant (Y2561) is more likely to have an effect on the arrangement of the C4 domain with neighboring domains rather than impairing platelet integrin binding.

Authors: Emma-Ruoqi Xu, Sören von Bülow, Po-Chia Chen, Peter J. Lenting, Katra Kolšek, Camilo Aponte-Santamaría, Bernd Simon, Jaelle Foot, Tobias Obser, Reinhard Schneppenheim, Frauke Gräter, Cécile V. Denis, Matthias Wilmanns, Janosch Hennig

Date Published: 24th Jan 2019

Publication Type: Journal

Abstract

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Author: Stephan Hemri

Date Published: 2019

Publication Type: InCollection

Abstract

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Authors: Wei Zhang, Gang Mu, Chen Song, Gangui Yan, Vincent Heuveline

Date Published: 2019

Publication Type: Journal

Abstract

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Authors: Natalie J. Stanford, Martin Scharm, Paul D. Dobson, Martin Golebiewski, Michael Hucka, Varun B. Kothamachu, David Nickerson, Stuart Owen, Jürgen Pahle, Ulrike Wittig, Dagmar Waltemath, Carole Goble, Pedro Mendes, Jacky Snoep

Date Published: 2019

Publication Type: InBook

Abstract

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Author: Rudolf Biczok

Date Published: 2019

Publication Type: Master's Thesis

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