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1688 Publications visible to you, out of a total of 1688
Fine-Tuning of Sequence Specificity by Near Attack Conformations in Enzyme-Catalyzed Peptide Hydrolysis

Abstract

Not specified

Author: S. Kashif Sadiq

Date Published: 1st Jun 2020

Publication Type: Journal

Load-Balance and Fault-Tolerance for Massively Parallel Phylogenetic Inference

Abstract

Not specified

Author: Lukas Hubner

Date Published: 1st Jun 2020

Publication Type: Master's Thesis

Structural characterization of an Arf dimer interface: molecular mechanism of Arf‐dependent membrane scission

Abstract

Not specified

Authors: Petra Diestelkoetter‐Bachert, Rainer Beck, Inge Reckmann, Andrea Hellwig, Ana Garcia‐Saez, Monika Zelman‐Hopf, Anton Hanke, Ariane Nunes Alves, Rebecca C. Wade, Matthias P. Mayer, Felix Wieland

Date Published: 31st May 2020

Publication Type: Journal

RDA COVID-19 Recommendations and Guidelines

Abstract

This is the final version of the Recommendations and Guidelines from the RDA COVID19 Working Group, and has been endorsed through the official RDA process.

Author: RDA COVID-19 Working Group

Date Published: 28th May 2020

Publication Type: Manual

A large harvested corpus of location metonymy

Abstract

Not specified

Authors: Kevin Mathews, Michael Strube

Date Published: 11th May 2020

Publication Type: InProceedings

Mechanoradicals in tensed tendon collagen as a source of oxidative stress

Abstract (Expand)

As established nearly a century ago, mechanoradicals originate from homolytic bond scission in polymers. The existence, nature and biological relevance of mechanoradicals in proteins, instead, are … unknown. We here show that mechanical stress on collagen produces radicals and subsequently reactive oxygen species, essential biological signaling molecules. Electron-paramagnetic resonance (EPR) spectroscopy of stretched rat tail tendon, atomistic molecular dynamics simulations and quantum-chemical calculations show that the radicals form by bond scission in the direct vicinity of crosslinks in collagen. Radicals migrate to adjacent clusters of aromatic residues and stabilize on oxidized tyrosyl radicals, giving rise to a distinct EPR spectrum consistent with a stable dihydroxyphenylalanine (DOPA) radical. The protein mechanoradicals, as a yet undiscovered source of oxidative stress, finally convert into hydrogen peroxide. Our study suggests collagen I to have evolved as a radical sponge against mechano-oxidative damage and proposes a mechanism for exercise-induced oxidative stress and redox-mediated pathophysiological processes.

Authors: Christopher Zapp, Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Markus Kurth, David M Hudson, Davide Mercadante, Uladzimir Barayeu, Tobias P Dick, Vasyl Denysenkov, Thomas Prisner, Marina Bennati, Csaba Daday, Reinhard Kappl, Frauke Gräter

Date Published: 8th May 2020

Publication Type: Journal

Chromatosome Structure and Dynamics from Molecular Simulations

Abstract

Not specified

Authors: Mehmet Ali Öztürk, Madhura De, Vlad Cojocaru, Rebecca C. Wade

Date Published: 20th Apr 2020

Publication Type: Journal

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