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1579 Publications visible to you, out of a total of 1579
Comparison of Machine Learning Methods for Predicting Employee Absences

Abstract

Not specified

Authors: Alejandra Jayme, Philipp Lösel, Vincent Heuveline

Date Published: 4th May 2021

Publication Type: Unpublished

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2

Abstract

Not specified

Authors: Benedict-Tilman Berger, Marta Amaral, Daria B. Kokh, Ariane Nunes-Alves, Djordje Musil, Timo Heinrich, Martin Schröder, Rebecca Neil, Jing Wang, Iva Navratilova, Joerg Bomke, Jonathan M. Elkins, Susanne Müller, Matthias Frech, Rebecca C. Wade, Stefan Knapp

Date Published: 1st May 2021

Publication Type: Journal

A Bittersweet Computational Journey among Glycosaminoglycans

Abstract

Not specified

Authors: Giulia Paiardi, Maria Milanesi, Rebecca C. Wade, Pasqualina D’Ursi, Marco Rusnati

Date Published: 1st May 2021

Publication Type: Journal

Simulating the formation of \ensuremathη Carinae’s surrounding nebula through unstable triple evolution and stellar merger-induced eruption

Abstract

Not specified

Authors: Ryosuke Hirai, Philipp Podsiadlowski, Stanley P. Owocki, Fabian R. N. Schneider, Nathan Smith

Date Published: 1st May 2021

Publication Type: Journal

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure

Abstract (Expand)

Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch syndrome (LS), the most common … inherited CRC syndrome. However, a comprehensive understanding of the distribution of these pathways of carcinogenesis, which allows for tailored clinical treatment and even prevention, is still lacking. We suggest a linear dynamical system modeling the evolution of different pathways of colorectal carcinogenesis based on the involved driver mutations. The model consists of different components accounting for independent and dependent mutational processes. We define the driver gene mutation graphs and combine them using the Cartesian graph product. This leads to matrix components built by the Kronecker sum and product of the adjacency matrices of the gene mutation graphs enabling a thorough mathematical analysis and medical interpretation. Using the Kronecker structure, we developed a mathematical model which we applied exemplarily to the three pathways of colorectal carcinogenesis in LS. Beside a pathogenic germline variant in one of the DNA mismatch repair (MMR) genes, driver mutations in APC, CTNNB1, KRAS and TP53 are considered. We exemplarily incorporate mutational dependencies, such as increased point mutation rates after MMR deficiency, and based on recent experimental data, biallelic somatic CTNNB1 mutations as common drivers of LS-associated CRCs. With the model and parameter choice, we obtained simulation results that are in concordance with clinical observations. These include the evolution of MMR-deficient crypts as early precursors in LS carcinogenesis and the influence of variants in MMR genes thereon. The proportions of MMR-deficient and MMR-proficient APC-inactivated crypts as first measure for the distribution among the pathways in LS-associated colorectal carcinogenesis are compatible with clinical observations. The approach provides a modular framework for modeling multiple pathways of carcinogenesis yielding promising results in concordance with clinical observations in LS CRCs.

Authors: Saskia Haupt, Alexander Zeilmann, Aysel Ahadova, Hendrik Bläker, Magnus von Knebel Doeberitz, Matthias Kloor, Vincent Heuveline

Date Published: 1st May 2021

Publication Type: Journal

From spontaneous to strategic natural window ventilation: Improving indoor air quality in Swiss schools

Abstract

Not specified

Authors: Claudia C. Vassella, Jeremy Koch, Alexander Henzi, Alexander Jordan, Roger Waeber, Reto Iannaccone, Roland Charrière

Date Published: 1st May 2021

Publication Type: Journal

Scoring interval forecasts: Equal-tailed, shortest, and modal interval

Abstract

Not specified

Authors: Jonas R. Brehmer, Tilmann Gneiting

Date Published: 1st May 2021

Publication Type: Journal

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