Publications

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1702 Publications visible to you, out of a total of 1702

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Authors: Zheng-Wei Liu, Friedrich K. Röpke, Yaotian Zeng, Alexander Heger

Date Published: 1st Oct 2021

Publication Type: Journal

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Author: K. Maltsev

Date Published: 1st Oct 2021

Publication Type: InProceedings

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Authors: Sucheta Ghosh, Pamela Wronski, Jan Koetsenruijter, Wolfgang Mueller, Michel Wensing

Date Published: 27th Sep 2021

Publication Type: Journal

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Authors: Daniele Alessandrini, Valentina Disarlo

Date Published: 8th Sep 2021

Publication Type: Journal

Abstract (Expand)

Type I collagen is the main structural component of many tissues in the human body. It provides excellent mechanical properties to connective tissue and acts as a protein interaction hub. There is thus a wide interest in understanding the properties and diverse functions of type I collagen at the molecular level. A precondition is an atomistic collagen I structure as it occurs in native tissue. To this end, we built full-atom models of cross-linked collagen fibrils by integrating the low-resolution structure of collagen fibril available from x-ray fiber diffraction with high-resolution structures of short collagen-like peptides from x-ray crystallography and mass spectrometry data. We created a Web resource of collagen models for 20 different species with a large variety of cross-link types and localization within the fibril to facilitate structure-based analyses and simulations of type I collagen in health and disease. To easily enable simulations, we provide parameters of the modeled cross-links for an Amber force field. The repository of collagen models is available at https://colbuilder.h-its.org.

Authors: Agnieszka Obarska-Kosinska, Benedikt Rennekamp, Aysecan Ünal, Frauke Gräter

Date Published: 7th Sep 2021

Publication Type: Journal

Abstract (Expand)

This article describes some use case studies and self-assessments of FAIR status of de.NBI services to illustrate the challenges and requirements for the definition of the needs of adhering to the FAIR (findable, accessible, interoperable and reusable) data principles in a large distributed bioinformatics infrastructure. We address the challenge of heterogeneity of wet lab technologies, data, metadata, software, computational workflows and the levels of implementation and monitoring of FAIR principles within the different bioinformatics sub-disciplines joint in de.NBI. On the one hand, this broad service landscape and the excellent network of experts are a strong basis for the development of useful research data management plans. On the other hand, the large number of tools and techniques maintained by distributed teams renders FAIR compliance challenging.

Authors: G. Mayer, W. Muller, K. Schork, J. Uszkoreit, A. Weidemann, U. Wittig, M. Rey, C. Quast, J. Felden, F. O. Glockner, M. Lange, D. Arend, S. Beier, A. Junker, U. Scholz, D. Schuler, H. A. Kestler, D. Wibberg, A. Puhler, S. Twardziok, J. Eils, R. Eils, S. Hoffmann, M. Eisenacher, M. Turewicz

Date Published: 2nd Sep 2021

Publication Type: Journal

Abstract

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Authors: Madhura De, Mehmet Ali Öztürk, Sebastian Isbaner, Katalin Tóth, Rebecca C. Wade

Date Published: 1st Sep 2021

Publication Type: Journal

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