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Innovative Tools Fostered by the HiPS Ecosystem

Abstract (Expand)

Over the past 10 years HiPS (Hierarchical Progressive Surveys) has evolved from an experiment led by CDS to an ecosystem supported by more than 20 data centers exposing their own HiPS node. This trend … has been pushed by advanced and simple clients (Aladin Desktop, Aladin Lite) or portals (ESASky, ESO Science Portal) and thanks to Hipsgen. Today the HiPS ecosystem gathers 900 HiPS datasets published by 20+ HiPS nodes. We describe a selection of different tools and services that benefit from having a large collection of multi-wavelength datasets available in the same format: hips2fits, on-the-fly generation of RGB tiles from pre-existing HiPS, HiPS as a container for 1d and 2d histograms, CatTiler, computation on the HiPS grid, generation of Spectral Energy Distribution from FITS tiles.

Authors: Thomas Boch, Mark Allen, Caroline Bot, Pierre Fernique, Matthieu Baumann, Mihaela Buga, Francois Bonnarel, Daniel Durand, Kai Polsterer

Date Published: 1st Jul 2022

Publication Type: InProceedings

Interactive Exploration Framework for Big Data Sets

Abstract (Expand)

Big data issues are the order of the day for many researchers in astronomy. In the past, several machine learning methods were proposed to organize, classify, or condense big data sets. However, this … is not the end of the road. In most cases, researchers need to take further analysis by hand on automatically preprocessed data to gather valuable conclusions. To facilitate the pipeline of data analysis, we suggest a generic front-end framework allowing the user not only to process the data automatically, but also to interactively explore and investigate the results of machine learning procedures. A compact visualization gives an initial overview and can be adjusted to point out the parts of interest. By providing abstract accommodation functions such as zooming, scrolling, filtering, and labeling, crucial data fragments can be found and marked in an intuitive way.

Authors: Fenja Kollasch, Kai Polsterer

Date Published: 1st Jul 2022

Publication Type: InProceedings

On the energy consumption of online and on-site lectures

Abstract

Not specified

Authors: Alexander Holas, Catherine Y. Koch, Joachim Leibold, Alesia Prendi, Tim P. Schlachta, Anna Sophia Schmid, Leonard Schmitt

Date Published: 22nd Jun 2022

Publication Type: Journal

From Easy to Hopeless - Predicting the Difficulty of Phylogenetic Analyses

Abstract

Not specified

Authors: Julia Haag, Dimitri Höhler, Ben Bettisworth, Alexandros Stamatakis

Date Published: 21st Jun 2022

Publication Type: Journal

A Conformational Transition of the D’D3 Domain primes von Willebrand Factor for Multimerization

Abstract (Expand)

Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the (trans-)Golgi is … still not fully understood. We use the single-molecule force spectroscopy technique magnetic tweezers to analyze a previously hypothesized conformational change in the D’D3 domain crucial for VWF multimerization. We find that the interface formed by submodules C8-3, TIL3, and E3 wrapping around VWD3 can open and expose two buried cysteines, Cys1099 and Cys1142, that are vital for multimerization. By characterizing the conformational change at varying levels of force, we are able to quantify the kinetics of the transition and the stability of the interface. We find a pronounced destabilization of the interface upon lowering the pH from 7.4 to 6.2 and 5.5. This is consistent with initiation of the conformational change that enables VWF multimerization at the D’D3 domain by a decrease in pH in the trans-Golgi network and Weibel-Palade bodies. Furthermore, we find a stabilization of the interface in the presence of coagulation factor VIII (FVIII), providing evidence for a previously hypothesized binding site in submodule C8-3. Our findings highlight the critical role of the D’D3 domain in VWF biosynthesis and function and we anticipate our methodology to be applicable to study other, similar conformational changes in VWF and beyond.

Authors: Sophia Gruber, Achim Löf, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser, Gesa König, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gräter, Maria A. Brehm, Martin Benoit, Jan Lipfert

Date Published: 2nd Jun 2022

Publication Type: Journal

Regression-based expected shortfall backtesting

Abstract

Not specified

Authors: Sebastian Bayer, Timo Dimitriadis

Date Published: 1st Jun 2022

Publication Type: Journal

Receiver operating characteristic (ROC) curves: Equivalences, beta model, and minimum distance estimation

Abstract

Not specified

Authors: Tilmann Gneiting, Peter Vogel

Date Published: 1st Jun 2022

Publication Type: Journal

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