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99 Publications visible to you, out of a total of 99
Comparison of Machine Learning Methods for Predicting Employee Absences

Abstract

Not specified

Authors: Alejandra Jayme, Philipp Lösel, Vincent Heuveline

Date Published: 4th May 2021

Publication Type: Unpublished

Mathematical modeling of multiple pathways in colorectal carcinogenesis using dynamical systems with Kronecker structure

Abstract (Expand)

Like many other types of cancer, colorectal cancer (CRC) develops through multiple pathways of carcinogenesis. This is also true for colorectal carcinogenesis in Lynch syndrome (LS), the most common … inherited CRC syndrome. However, a comprehensive understanding of the distribution of these pathways of carcinogenesis, which allows for tailored clinical treatment and even prevention, is still lacking. We suggest a linear dynamical system modeling the evolution of different pathways of colorectal carcinogenesis based on the involved driver mutations. The model consists of different components accounting for independent and dependent mutational processes. We define the driver gene mutation graphs and combine them using the Cartesian graph product. This leads to matrix components built by the Kronecker sum and product of the adjacency matrices of the gene mutation graphs enabling a thorough mathematical analysis and medical interpretation. Using the Kronecker structure, we developed a mathematical model which we applied exemplarily to the three pathways of colorectal carcinogenesis in LS. Beside a pathogenic germline variant in one of the DNA mismatch repair (MMR) genes, driver mutations in APC, CTNNB1, KRAS and TP53 are considered. We exemplarily incorporate mutational dependencies, such as increased point mutation rates after MMR deficiency, and based on recent experimental data, biallelic somatic CTNNB1 mutations as common drivers of LS-associated CRCs. With the model and parameter choice, we obtained simulation results that are in concordance with clinical observations. These include the evolution of MMR-deficient crypts as early precursors in LS carcinogenesis and the influence of variants in MMR genes thereon. The proportions of MMR-deficient and MMR-proficient APC-inactivated crypts as first measure for the distribution among the pathways in LS-associated colorectal carcinogenesis are compatible with clinical observations. The approach provides a modular framework for modeling multiple pathways of carcinogenesis yielding promising results in concordance with clinical observations in LS CRCs.

Authors: Saskia Haupt, Alexander Zeilmann, Aysel Ahadova, Hendrik Bläker, Magnus von Knebel Doeberitz, Matthias Kloor, Vincent Heuveline

Date Published: 1st May 2021

Publication Type: Journal

Biomechanics applied to incisional hernia repair – Considering the critical and the gained resistance towards impacts related to pressure

Abstract

Not specified

Authors: F. Kallinowski, Y. Ludwig, T. Löffler, M. Vollmer, P.D. Lösel, S. Voß, J. Görich, V. Heuveline, R. Nessel

Date Published: 1st Feb 2021

Publication Type: Journal

A Simple Model for Portable and Fast Prediction of Execution Time and Power Consumption of GPU Kernels

Abstract

Not specified

Authors: Lorenz Braun, Sotirios Nikas, Chen Song, Vincent Heuveline, Holger Fröning

Date Published: 21st Jan 2021

Publication Type: Journal

New Time Step Strategy for Multi-period Optimal Power Flow Problems

Abstract

Not specified

Authors: Nils Schween, Philipp Gerstner, Nico Meyer-Hübner, Vincent Heuveline

Date Published: 2021

Publication Type: InBook

Computational model investigates the evolution of colonic crypts during Lynch syndrome carcinogenesis

Abstract

Not specified

Authors: Saskia Haupt, Nils Gleim, Aysel Ahadova, Hendrik Bläker, Magnus von Knebel Doeberitz, Matthias Kloor, Vincent Heuveline

Date Published: 29th Dec 2020

Publication Type: Unpublished

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

Abstract

Not specified

Authors: Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor

Date Published: 1st Dec 2020

Publication Type: Journal

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