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A unique profilin-actin interface is important for malaria parasite motility

Abstract (Expand)

Author summary The malaria parasite Plasmodium has two invasive forms that migrate across different tissue barriers, the ookinete and the very rapidly migrating sporozoite. Previous work has shown that … the motility of these and related parasites (e.g. Toxoplasma gondii) depends on a highly dynamic actin cytoskeleton and retrograde flow of surface adhesins. These unusual actin dynamics are due to the divergent structure of protozoan actins and the actions of actin-binding proteins, which can have non-canonical functions in these parasites. Profilin is one of the most important and most investigated actin-binding proteins, which binds ADP-actin and catalyzes ADP-ATP exchange to then promote actin polymerization. Parasite profilins bind monomeric actin and contain an additional domain compared to canonical profilins. Here we show that this additional domain of profilin is critical for actin binding and rapid sporozoite motility but has little impact on the slower ookinete. Sporozoites of a parasite line carrying mutations in this domain cannot translate force production and retrograde flow into optimal parasite motility. Using molecular dynamics simulations, we find that differences between mutant parasites in their capacity to migrate can be traced back to a single hydrogen bond at the actin-profilin interface.

Authors: Catherine A. Moreau, Saligram P. Bhargav, Hirdesh Kumar, Katharina A. Quadt, Henni Piirainen, Léanne Strauss, Jessica Kehrer, Martin Streichfuss, Joachim P. Spatz, Rebecca C. Wade, Inari Kursula, Friedrich Frischknecht

Date Published: 26th May 2017

Publication Type: Journal

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes.

Abstract

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Authors: Nadinath B Nillegoda, Antonia Stank, Duccio Malinverni, Niels Alberts, Anna Szlachcic, Alessandro Barducci, Paolo De Los Rios, Rebecca C Wade, Bernd Bukau

Date Published: 15th May 2017

Publication Type: Journal

Generalised model-independent characterisation of strong gravitational lenses. I. Theoretical foundations

Abstract

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Author: J. Wagner

Date Published: 1st May 2017

Publication Type: Journal

A Critical Review on the Use of Support Values in Tree Viewers and Bioinformatics Toolkits

Abstract

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Authors: Lucas Czech, Jaime Huerta-Cepas, Alexandros Stamatakis

Date Published: 22nd Mar 2017

Publication Type: Journal

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity

Abstract

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Authors: Flavio Di Pisa, Giacomo Landi, Lucia Dello Iacono, Cecilia Pozzi, Chiara Borsari, Stefania Ferrari, Matteo Santucci, Nuno Santarem, Anabela Cordeiro-da-Silva, Carolina Moraes, Laura Alcantara, Vanessa Fontana, Lucio Freitas-Junior, Sheraz Gul, Maria Kuzikov, Birte Behrens, Ina Pöhner, Rebecca Wade, Maria Costi, Stefano Mangani

Date Published: 1st Mar 2017

Publication Type: Journal

Constructing stable 3D hydrodynamical models of giant stars

Abstract

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Authors: Sebastian T. Ohlmann, Friedrich K. Röpke, Rüdiger Pakmor, Volker Springel

Date Published: 1st Mar 2017

Publication Type: Journal

Combustion in thermonuclear supernova explosions

Abstract

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Author: F. K. Röpke

Date Published: 1st Mar 2017

Publication Type: InCollection

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