Publications

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1699 Publications visible to you, out of a total of 1699

Abstract

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Authors: Christine E. Collins, Stuart A. Sim, Luke J. Shingles, Sabrina Gronow, Friedrich K. Röpke, Rüdiger Pakmor, Ivo R. Seitenzahl, Markus Kromer

Date Published: 1st Sep 2023

Publication Type: Journal

Abstract (Expand)

Abstract Taxonomic assignment of operational taxonomic units (OTUs) is an important bioinformatics step in analyzing environmental sequencing data. Pairwise alignment and phylogenetic‐placement methodsogenetic‐placement methods represent two alternative approaches to taxonomic assignments, but their results can differ. Here we used available colpodean ciliate OTUs from forest soils to compare the taxonomic assignments of VSEARCH (which performs pairwise alignments) and EPA‐ng (which performs phylogenetic placements). We showed that when there are differences in taxonomic assignments between pairwise alignments and phylogenetic placements at the subtaxon level, there is a low pairwise similarity of the OTUs to the reference database. We then showcase how the output of EPA‐ng can be further evaluated using GAPPA to assess the taxonomic assignments when there exist multiple equally likely placements of an OTU, by taking into account the sum over the likelihood weights of the OTU placements within a subtaxon, and the branch distances between equally likely placement locations. We also inferred the evolutionary and ecological characteristics of the colpodean OTUs using their placements within subtaxa. This study demonstrates how to fully analyze the output of EPA‐ng, by using GAPPA in conjunction with knowledge of the taxonomic diversity of the clade of interest.

Authors: Isabelle Ewers, Lubomír Rajter, Lucas Czech, Frédéric Mahé, Alexandros Stamatakis, Micah Dunthorn

Date Published: 1st Sep 2023

Publication Type: Journal

Abstract

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Authors: M. Bernini-Peron, W. L. F. Marcolino, A. A. C. Sander, J. -C. Bouret, V. Ramachandran, J. Saling, F. R. N. Schneider, L. M. Oskinova, F. Najarro

Date Published: 1st Sep 2023

Publication Type: Journal

Abstract

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Authors: Nikos I. Bosse, Sam Abbott, Anne Cori, Edwin van Leeuwen, Johannes Bracher, Sebastian Funk

Date Published: 29th Aug 2023

Publication Type: Journal

Abstract

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Author: Michel Tarnow

Date Published: 22nd Aug 2023

Publication Type: Bachelor's Thesis

Abstract

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Authors: Lucas G. Viviani, Daria B. Kokh, Rebecca C. Wade, Antonia T.-do Amaral

Date Published: 14th Aug 2023

Publication Type: Journal

Abstract (Expand)

The Metadata Schema of the NFDI4Health and the NFDI4Health Task Force COVID-19 (Metadata Schema) contains a list of properties that describe a resource to be registered in the German Central Health Study Hub. Currently, two main types of resources are distinguished: a) study descriptions (i.e., metadata set describing a study) and b) study documents. However, due to the generic character of the Metadata Schema, other types of resources may also be described and registered. The metadata properties are divided into mandatory and recommended ones. Along with bibliographic information such as title and description of the resource, the related persons and organizations contributing to the development of the resource can also be specified. The results of studies published in journal articles or other text publications can be linked too. For studies, information about study design and accessibility of the collected data should be additionally provided. The Metadata Schema consists mainly of properties adapted from established standards and models such as DataCite Metadata Schema 4.4, data models of the ClinicalTrials.gov, German Clinical Trials Register, International Clinical Trials Registry, HL7® FHIR, MIABIS, Maelstrom Research cataloguing toolkit and DDI Controlled Vocabularies. This is an updated version V3_2 of the Metadata Schema, which improves the modules of the previous version via refined description texts and added, deleted, moved, or renamed items. Additional use case-specific requirements, particularly for the chronic diseases and record linkage modules, have also been considered in this new version along with updating the list of sources. The undertaken changes are described within the document.

Authors: Haitham Abaza, A. Shutsko, Martin Golebiewski, Sophie Klopfenstein, Carsten Oliver Schmidt, Carina Vorisek, NFDI4Health Task Force COVID-19, NFDI4Health, C. Brünings-Kuppe, V. Clemens, J. Darms, S. Hanß, T. Intemann, F. Jannasch, E. Kasbohm, Birte Lindstädt, Matthias Löbe, E. Orban, I. Perrar, M. Peters, U. Sax, M. Schulze, C. Schupp, F. Schwarz, C. Schwedhelm, S. Strathmann, Dagmar Waltemath, H. Wünsche, A. Zeleke

Date Published: 14th Aug 2023

Publication Type: Misc

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