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Enzyme kinetics informatics: from instrument to browser.

Abstract (Expand)

A limited number of publicly available resources provide access to enzyme kinetic parameters. These have been compiled through manual data mining of published papers, not from the original, raw … experimental data from which the parameters were calculated. This is largely due to the lack of software or standards to support the capture, analysis, storage and dissemination of such experimental data. Introduced here is an integrative system to manage experimental enzyme kinetics data from instrument to browser. The approach is based on two interrelated databases: the existing SABIO-RK database, containing kinetic data and corresponding metadata, and the newly introduced experimental raw data repository, MeMo-RK. Both systems are publicly available by web browser and web service interfaces and are configurable to ensure privacy of unpublished data. Users of this system are provided with the ability to view both kinetic parameters and the experimental raw data from which they are calculated, providing increased confidence in the data. A data analysis and submission tool, the kineticswizard, has been developed to allow the experimentalist to perform data collection, analysis and submission to both data resources. The system is designed to be extensible, allowing integration with other manufacturer instruments covering a range of analytical techniques.

Authors: N. Swainston, M. Golebiewski, H. L. Messiha, N. Malys, R. Kania, S. Kengne, O. Krebs, S. Mir, H. Sauer-Danzwith, K. Smallbone, A. Weidemann, U. Wittig, D. B. Kell, P. Mendes, W. Muller, N. W. Paton, I. Rojas

Date Published: 27th Aug 2010

Publication Type: Journal

Biochemical network-based drug-target prediction

Abstract

Not specified

Authors: Edda Klipp, Rebecca C Wade, Ursula Kummer

Date Published: 1st Aug 2010

Publication Type: Journal

The LUCIFER control software

Abstract

Not specified

Authors: Marcus Jütte, Volker Knierim, Kai Polsterer, Michael Lehmitz, Clemens Storz, Walter Seifert, Nancy Ageorges

Date Published: 19th Jul 2010

Publication Type: Journal

LUCIFER1 commissioning at the LBT

Abstract

Not specified

Authors: N. Ageorges, W. Seifert, M. Jütte, V. Knierim, M. Lehmitz, A. Germeroth, P. Buschkamp, K. Polsterer, A. Pasquali, V. Naranjo, H. Gemperlein, J. Hill, C. Feiz, R. Hofmann, W. Laun, R. Lederer, R. Lenzen, U. Mall, H. Mandel, P. Müller, A. Quirrenbach, L. Schäffner, C. Storz, P. Weiser

Date Published: 13th Jul 2010

Publication Type: Journal

The LUCIFER MOS: a full cryogenic mask handling unit for a near-infrared multi-object spectrograph

Abstract

Not specified

Authors: Peter Buschkamp, Reiner Hofmann, Hans Gemperlein, Kai Polsterer, Nancy Ageorges, Frank Eisenhauer, Reinhard Lederer, Mathias Honsberg, Marcus Haug, Johann Eibl, Walter Seifert, Reinhard Genzel

Date Published: 13th Jul 2010

Publication Type: Journal

LUCIFER1: performance results

Abstract

Not specified

Authors: Walter Seifert, Nancy Ageorges, Michael Lehmitz, Peter Buschkamp, Volker Knierim, Kai Polsterer, Andre Germeroth, Anna Pasquali, Vianak Naranjo, Marcus Jütte, Carmen Feiz, Hans Gemperlein, Reiner Hofmann, Werner Laun, Reinhard Lederer, Rainer Lenzen, Ulrich Mall, Holger Mandel, Peter Müller, Andreas Quirrenbach, Ludwig Schäffner, Clemens Storz, Peter Weiser

Date Published: 13th Jul 2010

Publication Type: Journal

Kinetics of Biomacromolecular Complex Formation: Theory and Experiment

Abstract

Not specified

Authors: Georgi V. Pachov, Razif R. Gabdoulline, Rebecca C. Wade

Date Published: 1st May 2010

Publication Type: InBook

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