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352 Publications visible to you, out of a total of 352
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2

Abstract

Not specified

Authors: Benedict-Tilman Berger, Marta Amaral, Daria B. Kokh, Ariane Nunes-Alves, Djordje Musil, Timo Heinrich, Martin Schröder, Rebecca Neil, Jing Wang, Iva Navratilova, Joerg Bomke, Jonathan M. Elkins, Susanne Müller, Matthias Frech, Rebecca C. Wade, Stefan Knapp

Date Published: 1st May 2021

Publication Type: Journal

A Bittersweet Computational Journey among Glycosaminoglycans

Abstract

Not specified

Authors: Giulia Paiardi, Maria Milanesi, Rebecca C. Wade, Pasqualina D’Ursi, Marco Rusnati

Date Published: 1st May 2021

Publication Type: Journal

Line-FRAP, A Versatile Method to Measure Diffusion Rates In Vitro and In Vivo

Abstract

Not specified

Authors: Debabrata Dey, Shir Marciano, Ariane Nunes-Alves, Vladimir Kiss, Rebecca C Wade, Gideon Schreiber

Date Published: 1st Apr 2021

Publication Type: Journal

A function of profilin in force generation during malaria parasite motility that is independent of actin binding

Abstract (Expand)

During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding … motility is based on retrograde flow of membrane proteins and highly dynamic actin filaments that provide short tracks for a myosin motor. Using laser tweezers and parasite mutants, we previously suggested that actin filaments form macromolecular complexes with plasma membrane-spanning adhesins to generate force during migration. Mutations in the actin-binding region of profilin, a near ubiquitous actin-binding protein, revealed that loss of actin binding also correlates with loss of force production and motility. Here, we show that different mutations in profilin, that do not affect actin binding in vitro, still generate lower force during Plasmodium sporozoite migration. Lower force generation inversely correlates with increased retrograde flow suggesting that, like in mammalian cells, the slow down of flow to generate force is the key underlying principle governing Plasmodium gliding motility.

Authors: Catherine A. Moreau, Katharina A. Quadt, Henni Piirainen, Hirdesh Kumar, Saligram P. Bhargav, Léanne Strauss, Niraj H. Tolia, Rebecca C. Wade, Joachim P. Spatz, Inari Kursula, Friedrich Frischknecht

Date Published: 2021

Publication Type: Journal

A Protocol to Use Comparative Binding Energy Analysis to Estimate Drug-Target Residence Time

Abstract

Not specified

Authors: Gaurav K. Ganotra, Ariane Nunes-Alves, Rebecca C. Wade

Date Published: 2021

Publication Type: InBook

Ligand unbinding mechanisms and kinetics for T4 lysozyme mutants from τRAMD simulations

Abstract

Not specified

Authors: Ariane Nunes-Alves, Daria B. Kokh, Rebecca C. Wade

Date Published: 2021

Publication Type: Journal

The Effect of Force-Field Parameters on Cytochrome P450-Membrane Interactions: Structure and Dynamics

Abstract

Not specified

Authors: Ghulam Mustafa, Prajwal P. Nandekar, Goutam Mukherjee, Neil J. Bruce, Rebecca C. Wade

Date Published: 1st Dec 2020

Publication Type: Journal

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