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Abstract (Expand)
erroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to membrane damage and rupture. Here we show that enzymatically produced sulfane sulfur (S0) species, specifically … hydropersulfides, scavenge endogenously generated free radicals and, thereby, suppress lipid peroxidation and ferroptosis. By providing sulfur for S0 biosynthesis, cysteine can support ferroptosis resistance independently of the canonical GPX4 pathway. Our results further suggest that hydropersulfides terminate radical chain reactions through the formation and self-recombination of perthiyl radicals. The autocatalytic regeneration of hydropersulfides may explain why low micromolar concentrations of persulfides suffice to produce potent cytoprotective effects on a background of millimolar concentrations of glutathione. We propose that increased S0 biosynthesis is an adaptive cellular response to radical-driven lipid peroxidation, potentially representing a primordial radical protection system.
Authors: Uladzimir Barayeu, Danny Schilling, Mohammad Eid, Thamara Nishida Xavier da Silva, Lisa Schlicker, Nikolina Mitreska, Christopher Zapp, Frauke Gräter, Aubry K. Miller, Reinhard Kappl, Almut Schulze, José Pedro Friedmann Angeli, Tobias P. Dick
Date Published: 15th Sep 2022
Publication Type: Journal
DOI: 10.1038/s41589-022-01145-w
Citation: Nature Chemical Biology 19: 28–37
Created: 27th Sep 2022 at 09:55, Last updated: 5th Mar 2024 at 21:24
Abstract
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Authors: Benedikt Rennekamp, Fabian Kutzki, Agnieszka Obarska-Kosinska, Christopher Zapp, Frauke Gräter
Date Published: 16th Jan 2020
Publication Type: Journal
Created: 5th Mar 2020 at 12:52, Last updated: 5th Mar 2024 at 21:24